{"id":2831,"date":"2021-05-22T20:01:22","date_gmt":"2021-05-22T20:01:22","guid":{"rendered":"https:\/\/imcedu.com\/new\/?page_id=2831"},"modified":"2024-05-10T04:44:42","modified_gmt":"2024-05-10T04:44:42","slug":"a-comprehensive-study-on-chronic-kidney-disease-of-uncertain-etiology","status":"publish","type":"page","link":"https:\/\/www.nrc.gov.lk\/index.php\/a-comprehensive-study-on-chronic-kidney-disease-of-uncertain-etiology\/","title":{"rendered":"A Comprehensive Study on Chronic Kidney Disease of uncertain Etiology"},"content":{"rendered":"<style type=\"text\/css\">@media only screen and (min-width: 1000px) and (max-width: 5000px){body.kc-css-system .kc-css-2538544{width: 33.33%;}body.kc-css-system .kc-css-1775515{width: 33.33%;}body.kc-css-system .kc-css-4150228{width: 33.33%;}body.kc-css-system .kc-css-284036{width: 50%;}body.kc-css-system .kc-css-1818752{width: 50%;}body.kc-css-system .kc-css-1390838{width: 100%;}body.kc-css-system .kc-css-3762932{width: 24.81%;}body.kc-css-system .kc-css-4094880{width: 22.33%;}body.kc-css-system .kc-css-636232{width: 52.81%;}}body.kc-css-system .kc-css-2937393{height: 20px;}body.kc-css-system .kc-css-2497443{padding-top: 50px;padding-bottom: 50px;}body.kc-css-system .kc-css-1243204 ,body.kc-css-system .kc-css-1243204 p{color: #000000;}body.kc-css-system .kc-css-1243204{background: #ffffff;}body.kc-css-system .kc-css-1818752{padding-left: 8%;}@media only screen and (max-width: 999px){body.kc-css-system .kc-css-284036{margin-left: 0%;width: 100%;}body.kc-css-system .kc-css-1818752{margin-left: 0%;width: 100%;padding-top: 10px;padding-left: 15px;}}<\/style>\n<section class=\"kc-elm kc-css-3934559 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-960086 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-3924606 kc-title-wrap \">\n<h2 class=\"kc_title page-title font-md lil-line\">A Comprehensive Study on Chronic Kidney Disease of uncertain Etiology<\/h2>\n<\/div>\n<div class=\"kc-elm kc-css-1815402\" style=\"height: 20px; clear: both; width:100%;\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-724645 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-2538544 kc_col-sm-4 kc_column kc_col-sm-4\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-2937393 kc_box_wrap \">\n<div>\n<div class=\"one-one\">\n<p><b>NRC Grant No:<\/b>&nbsp; &nbsp; NRC TO 14-05 <span style=\"color: #000000; font-family: Arial, Helvetica, sans-serif; font-size: 13.3333px; text-align: start;\">&nbsp;<\/span>&nbsp;<\/p>\n<p><b>Research Institute: <\/b>University of Peradeniya<\/p>\n<p><b>Amount Funded:<\/b> Rs. 49,300,000.00<\/p>\n<p><b>Date of Awarded:<\/b> 28<sup>th<\/sup>&nbsp;August 2014<\/p>\n<p><b>End Date:<\/b> 28<sup>th<\/sup>&nbsp;August 2019<\/p>\n<p><strong><text>Status:<\/text><\/strong><text>&nbsp;&nbsp;<\/text>Completed<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"kc-elm kc-css-1775515 kc_col-sm-4 kc_column kc_col-sm-4\">\n<div class=\"kc-col-container\">\n<article class=\"sabbi-thumlinepost-card solitude-bg__x kc-elm kc-css-3241838\">\n<figure class=\"sabbi-thumlinepost-card-figure\">\n                           <img width=\"271\" height=\"211\" src=\"https:\/\/www.nrc.gov.lk\/wp-content\/uploads\/2021\/05\/Prof_RohanaChandrajith.jpg\" class=\"img-responsive img-thumpost\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><br \/>\n                          <\/figure>\n<div class=\"sabbi-thumlinepost-card-meta\">\n<h2 class=\"info-box-title ht-5\">Principal Investigator<br \/>\n<\/h2>\n<p>Prof. Rohana Chandrajith<br \/>\nUniversity of Peradeniya<\/p>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<div class=\"kc-elm kc-css-4150228 kc_col-sm-4 kc_column kc_col-sm-4\">\n<div class=\"kc-col-container\">\n<article class=\"sabbi-thumlinepost-card solitude-bg__x kc-elm kc-css-4276935\">\n<figure class=\"sabbi-thumlinepost-card-figure\">\n                           <img width=\"271\" height=\"211\" src=\"https:\/\/www.nrc.gov.lk\/wp-content\/uploads\/2021\/05\/Prof_Shirani_Ranasinghe.jpg\" class=\"img-responsive img-thumpost\" alt=\"\" decoding=\"async\" loading=\"lazy\" \/><br \/>\n                          <\/figure>\n<div class=\"sabbi-thumlinepost-card-meta\">\n<h2 class=\"info-box-title ht-5\">Deputy Principal Investigator <\/h2>\n<p>Prof. Shirani Ranasinghe<br \/>\nUniversity of Peradeniya<\/p>\n<\/div>\n<\/article>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-2497443 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-284036 kc_col-sm-6 kc_column kc_col-sm-6\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-1243204 kc_text_block\">\n<h2>Summary<\/h2>\n<p style=\"text-align: justify;\">The prevalence of Chronic Kidney Diseases (CKD) is rising globally and is attributed to an epidemic of diabetes mellitus. The trend in the developing countries appears to be chronic glomerulonephritis and diabetes contributing significantly to the increasing end stage renal disease. In Sri Lanka, the prevalence of CKD has been increasing over a period of 10-15 years in certain parts of the island. However, it is found to be different and are not associated with known risk factors. Therefore, this disease is described as Chronic Kidney Diseases with uncertain etiology (CKDu). The research conducted up to date reveal the CKDu appears to be confined to specific geographical areas of the country. High prevalence of the disease is observed in Medawachchiya, Girandurukotte, Kabithigollawa, Padaviya, Medirigiriya, Vunniya, Dehiattakandiya, Nikawewa, Hettipola and Polpithigama. Majority of the population in the affected areas are farmers and the decease seems to manifests commonly in males although evidence for the contrary has also been produced. The histological appearance of the kidney disease is \u2018tubulo-interstitial\u2019 which is commonly observed in toxic nephropathies. The disease process appears to mainly affect the proximal tubules and the interstitium giving rise to characteristic, recognizable pathohistological and clinical features.<\/p>\n<p style=\"text-align: justify;\">After outbreak of the CKDu in Sri Lanka, large number of research studies has been conducted by various organizations and also identified several risk factors. Among the suspected nephrotoxic environmental factors attributed are high fluoride in drinking water, leaching aluminum from cooking utensils due to high fluoride water, algal toxin in water, arsenic in water due to use of agrochemicals, cadmium in water, fish and plants. Even though some studies suggested that heavy metals are the causative factor for CKDu, the fact that authors have not clearly explained the geographical biasness of the disease. Therefore, this aspect needs to be required further investigations. With systematic studies of populations for CKDu, in-depth histological, biochemical investigations, site investigations for geo-environmental analysis and other potential contributing factors; medical scientists, chemists and agriculturists would be in a better position to contribute towards the origin of the CKDu. Proper demarcation and mapping of the CKDu affected region, socio-economic study of the people living in the area and comparison of geo-environmental qualities with none CKDu areas are important for identifying the possible causative factors.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"kc-elm kc-css-1818752 kc_col-sm-6 kc_column kc_col-sm-6\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-2965264 kc_text_block\">\n<h2>Objectives<\/h2>\n<ul>\n<li>Retrospective cohort study<\/li>\n<li>Prospective cohort study (community surveillance study)<\/li>\n<li>Geo-environmental study<\/li>\n<li>Tissue culture study<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-3348407 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-1390838 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-3968681 kc_text_block\">\n<h2>Major Equipment Facilitated by Grant<\/h2>\n<ul>\n<li>Inductively coupled plasma spectrometer<\/li>\n<li>Inverted Epifluoroscence microscope system<\/li>\n<li>Biochemical analyser<\/li>\n<\/ul>\n<\/div>\n<div class=\"kc-elm kc-css-3868065 kc-title-wrap \">\n<h2 class=\"kc_title\">Research Team<\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-2919446 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-3762932 kc_col-sm-3 kc_column kc_col-sm-3\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-681062 kc_text_block\">\n<p><strong>Designation<\/strong><\/p>\n<p>Principal Investigator (PI)<\/p>\n<p>Deputy Principal Investigator (DPI)<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<p>Co- investigator<\/p>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"kc-elm kc-css-4094880 kc_col-of-5 kc_column kc_col-of-5\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-684240 kc_text_block\">\n<p><strong>Name<\/strong><\/p>\n<p>Prof. R. Chandrajith<\/p>\n<p>Prof. S. Ranasinghe<\/p>\n<p>Prof. O.A. Ileperuma<\/p>\n<p>Prof. R. Sivakaneshan<\/p>\n<p>Dr. B. Alexander<\/p>\n<p>Dr. N. Nanayakkara<\/p>\n<p>Dr. T. Abeysekera<\/p>\n<p>Dr. S. Yatigammana<\/p>\n<p>Prof. A.N. Navaratne<\/p>\n<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"kc-elm kc-css-636232 kc_col-sm-6 kc_column kc_col-sm-6\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-707591 kc_text_block\">\n<p><b>Institute<\/b><\/p>\n<p>Department of Geology Faculty of Science University of Peradeniya<\/p>\n<p>Department of Biochemistry Faculty of Medicine University of Peradeniya<\/p>\n<p>Department of Chemistry Faculty of Science University of Peradeniya<\/p>\n<p>Department of Biochemistry Faculty of Medicine University of Peradeniya<\/p>\n<p>Department of Farm Animal &#038; Production Health Faculty of Veterinary Medicine &#038; Animal Science University of Peradeniya<\/p>\n<p>Consultant Nephrologist Teaching Hospital, Kandy<\/p>\n<p>University of Peradeniya<\/p>\n<p>Department of Zoology Faculty of Science University of Peradeniya<\/p>\n<p>Department of Chemistry Faculty of Science University of Peradeniya<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-4046216 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-974174 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-798054\" style=\"height: 20px; clear: both; width:100%;\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"kc-elm kc-css-2439873 kc_row\">\n<div class=\"kc-row-container  kc-container\">\n<div class=\"kc-wrap-columns\">\n<div class=\"kc-elm kc-css-208627 kc_col-sm-12 kc_column kc_col-sm-12\">\n<div class=\"kc-col-container\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>A Comprehensive Study on Chronic Kidney Disease of uncertain Etiology NRC Grant No:&nbsp; &nbsp; NRC TO 14-05 &nbsp;&nbsp; Research Institute: University of Peradeniya Amount Funded: Rs. 49,300,000.00 Date of Awarded: 28th&nbsp;August 2014 End Date: 28th&nbsp;August 2019 Status:&nbsp;&nbsp;Completed Principal Investigator Prof. Rohana Chandrajith University of Peradeniya Deputy Principal Investigator Prof. Shirani Ranasinghe University of Peradeniya Summary [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":250,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-2831","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/pages\/2831","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/comments?post=2831"}],"version-history":[{"count":7,"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/pages\/2831\/revisions"}],"predecessor-version":[{"id":7278,"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/pages\/2831\/revisions\/7278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/media\/250"}],"wp:attachment":[{"href":"https:\/\/www.nrc.gov.lk\/index.php\/wp-json\/wp\/v2\/media?parent=2831"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}